Aherne, star and author of The Royle Family and The Mrs Merton Show, had suffered disease, her marketing specialist said.
The performer said two years back that she had been determined to have lung disease, having already had bladder and eye growth.
Aherne was additionally the storyteller of Gogglebox and showed up in The Fast Show.
Her marketing specialist Neil Reading said on Saturday: “Caroline Aherne has tragically passed away, after a fearless fight with malignancy.
“The Bafta grant winning author and comic drama on-screen character kicked the bucket before today at her home in Timperley, Greater Manchester. She was 52.
“The family request protection at this exceptionally pitiful time.”
Eulogy: Caroline Aherne
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‘Genuine comic drama virtuoso’s
Aherne had talked about her conclusion with disease while tending to a speak to favor malignancy care in Manchester in 2014, saying: “I’ve had tumor and my sibling’s had growth and we know how it influences individuals.”
She said she and her sibling had been conceived with malignancy of the retina, including: “My mum let us know that lone unique individuals get growth. I should be exceptionally unique since I’ve had it in my lungs and my bladder also.”
Aherne’s co-stars and kindred funnies have been paying tribute to her.
Sue Johnston, who played Barbara – the mother of Aherne’s character Denise – in The Royle Family, said: “I am crushed at her passing and I am numb with anguish.”
Ralf Little, Denise’s sibling Antony in the appear, said Aherne was “a sister, genuine and (for me) fake”, and also a virtuoso and a companion with a “major, huge heart”.
The Fast Show co-star Arabella Weir told the BBC Aherne was “a flat out virtuoso” and that “all that she said was interesting”.
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Media captionCaroline Aherne: How parody radio desolation close relative got to be TV star
She said: “She was one of those individuals who was – without being consideration looking for – dependably, constantly clever, notwithstanding when you weren’t recording.
“All that she said was just killingly interesting. She was only an incredible and she was a tender, kind, agreeable individual. She was incredible to work with. She never made a whine. She was only a genuine giggle to be around.”
Telecaster Terry Christian, who had additionally worked nearby Aherne, said: “What it was with Caroline was she was truly one of the most interesting individuals just in the bar.
“A considerable measure of entertainers aren’t. You know they leave, record it all and you know, all things considered, there’s nothing.
“Though with Caroline, she was so actually sharp and witty and that is the reason all that she did had that danger component in. You know whether you take a gander at the Mrs Merton Show, none of it was set up. Not a solitary inquiry with the crowd was set up.”